热痛定量感官测试仪-疼痛感觉测试设备
新型定量感官测试仪
世联博研（北京）科技有限公司——动物实验技术服务外包——更多信息，请联系：祝经理
第一个能够准确和可复制的接触性冷诱发电位的刺激器
准确·高效·MRI兼容
产品简介
一种新型皮肤热刺激疼痛研究仪器
设计为处于科学研究技术的最前沿。 内置阈值协议可通过用户友好的触摸屏轻松执行,使临床研究更加从容简单。
√300℃/秒的冷热刺激
√定量感官测试（低于 1 分钟的阈值）
√准确高效地进行疼痛研究
√第一款能够实现准确且可复制的接触冷诱发电位的刺激器
√最适合CHEPS 和 CCEPS
√核磁共振兼容
功能亮点
- 大温度范围
- 快速升温
- 高精度
- 多个独立的刺激区域
- 自动校准
- 自动调节至中性皮肤温度
- 电池供电
- 免维护
内置 QST 协议随时可用
易于编程的协议环境
可外接电脑驱动
所有探头都有多个独立区域，都可以制造成兼容 MRI 的版本
部分出版物参考
1. De Keyser R., van den Broeke E., Courtin A., Dufour A., Mouraux A. (2018). Event-related brain potentials elicited by high-speed cooling of the skin: A robust and non-painful method to assess the spinothalamic system in humans. Clinical Neurophysiology. 129(5), 1011-1019.
2. Lenoir C., Algoet M. & Mouraux A. (2018). Deep continuous theta burst stimulation of the opercula-insular cortex selectively affects Adelta fibre heat pain. The Journal of Physiology. 596(19), 4767-4787.
3. Mulders D., de Bodt C., Lejeune N., Courtin A., Liberati G., Verleysen M., Mouraux A. (2020). Dynamics of perception and EEG signals triggered by tonic warm and cool stimulation. Plos One, 15(4).
4. van Neerven S.G.A. and Mouraux A. (2020). Capsaicin-induced skin desensitization differentially affects A-delta and C-fiber-mediated heat sensitivity. Frontiers in Pharmacology. 11, 1-15
5. Leone C., Di Lionardo A., Diotallevi G., Mollico C, Di Pietro G., Di Stephano G., La Cesa S., Cruccu G., Truini A. (2020). Conduction velocity of the cold spinal pathway in healthy humans. European Journal of Pain. Online ahead of print doi: 10.1002/ejp.1640.
6. Liberati G., Mulders D., Algoed M., van den Broeke E., Ferrao Santos S., Géraldo Ribeiro Vaz J., Raftopoulos C., Mouraux A. (2020). Insular response to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG. Scientific Reports. 10:22319, 1-14.
7. Courtin A. & Mouraux A. (2021). Combining Topical Agonists With the Recording of Event-Related Brain Potentials to Probe the Functional Involvement of TRPM8, TRPA1 and TRPV1 in Heat and Cold Transduction in the Human Skin. The Journal of Pain. Epub, 1-18.
8. De Schoenmacker I., Archibald J., Kramer J.L.K. & Hubli M. (2022). Improved acquisition of contact heat evoked potentials with increased heating ramp. Scientific Reports, 12, 925.
9. Fabig S.C, Kersebaum D., Lassen J., Sendel Manon, Jendral S., Muntan A., Baron R. & Hüllemann P. (2021). A modality-specific somatosensory evoked potential test protocol for clinical evaluation: A feasibility study. Clinical Neurophysiology. 132, 3104-3115.
临床应用
Leone C., Dufour A., Di Stefano G., Fasolino A., Di Lionardo A., La Cesa S., Galosi E., Valeriani M.,Nolano M., Cruccu G. Truini A. (2019). Cooling the skin for assessing small-fibre function. Pain. 160(9), 1967-1975
采用自适应阶梯法的高灵敏度QST
1. Lithfous S., Després O, Pebayle T. & Dufour A. (2019). Modification of descending analgesia in aging: critical role of the prefrontal cortex.Clinical Journal of Pain. 35(1), 23-30.
2. Després O, Lithfous S, Pebayle T. Casadio C. & Dufour A. (2019). Effects of thermosensory aging well demonstrated by cold stimulation with high temporal resolution.Muscle Nerve. 60(2)., 141-146.
3. Lithfous S., Després O., Pebayle T., Casadio C. & Dufour A. (2020). Accurate determination of the cold detection threshold with high-speed cooling of the skin. Pain Medicine. online ahead of print.
模拟皮肤中的热扩散
Dufour A., Després O, Pebayle T. & Lithfous S. (2020). Thermal sensitivity in humans at the depth of thermal receptor endings beneath the skin: validation of a heat transfer model of the skin using high-temporal resolution stimuli. European Journal of Applied Physiology. 120, 1509-1518.
动物研究
Gieré C., Melchior M., Dufour A., Poisbeau P. (2021). Spinal integration of hot and cold nociceptive stimuli by wide dynamic range neurons in anesthetized adult rats. Pain Reports. Epub.
